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Sjögren’s Patients Fall into 4 Distinct Groups Depending on Symptoms, Study Suggests
“Conventionally, patients with primary Sjögren’s syndrome are thought to consist of two subtypes — those with predominantly glandular symptoms and those with extra-glandular (systemic) manifestations,” the study noted. “However, many patients do not fit neatly into these subtypes and no consensus criteria exist for such classification.”
Sjögren’s Patients Fall into 4 Distinct Groups Depending on Symptoms, Study Suggests
“Conventionally, patients with primary Sjögren’s syndrome are thought to consist of two subtypes — those with predominantly glandular symptoms and those with extra-glandular (systemic) manifestations,” the study noted. “However, many patients do not fit neatly into these subtypes and no consensus criteria exist for such classification.”
"The team sorted individuals based on five common disease symptoms: pain, fatigue, dryness, anxiety, and depression. At the simplest level, the sorting was done by feeding symptom data into a computer program, which grouped individuals with similar symptoms together.
This resulted in four subgroups, which the researchers dubbed: low symptom burden (LSB), high symptom burden (HSB), dryness dominant with fatigue (DDF), and pain dominant with fatigue (PDF)."
